In the heart of Hong Kong, amidst the bustling streets and the scent of the sea, the story of 'Call the Midwife' unfolds. Violet and Fred embark on a rare journey to visit Violet's son Derek, a dedicated policeman in the British colony. Their mission extends beyond family; they carry supplies to aid the Nonnatus House chapter in treating addicts and caring for orphans and pregnant women. Among these travelers is May Turner, once a resident of Hong Kong, whose mother, Esther, still calls this place home. The Turners send packages and photos to Esther via Violet and Fred, a gesture of love and connection. But their arrival coincides with a tragic scene: police block the street, and people flee from a cloud of dust. The Nonnatus House branch has collapsed, claiming lives and leaving many injured. Sister Hilda, the head of the order, rallies a team to support the Hong Kong chapter through this tragedy. Sisters Julienne and Veronica, Nurse Crane, and Dr. Turner join forces, with Dr. Turner inviting Shelagh to assist. However, Shelagh declines, citing her need in London. The midwives organize a donation drive for clothing, using a baby photo of May to promote the cause. May herself speaks to a radio reporter, emphasizing the drive's importance. She and her siblings urge Shelagh to join them in Hong Kong, and May donates the sweater she wore when she first arrived in England. Meanwhile, Cyril is also relocating for the holidays, renting his room to a wealthy man who wishes to support his church. Trixie, who has returned to London from New York, encounters a silver-handled cane in the snow near Cyril's apartment, recognizing it as belonging to a famous film actor. They find the actor, Mr. Fischer, fallen nearby, suffering from a blood disorder that will soon end his life. He decides to return to his childhood home to die, and Sister Monica Joan offers companionship as he convalesces in bed. In Poplar, the midwives face challenges, including a lack of experience in obstetrics. Diane Edgar's labor with a large baby prompts a call for Sister Monica Joan's expertise. The midwives successfully deliver the baby using gravity, avoiding the need for forceps. Back in Hong Kong, the midwives navigate a web of organized crime, known as the triad, which controls the area. Shelagh searches for May's mother, Esther, but encounters resistance. Grace, a woman who introduces herself as Esther's acquaintance, pleads with Shelagh to leave. Sister Julienne and Sister Hilda secure a new clinic, with Violet promising funds from philanthropists. However, Grace's husband, a triad member, demands the keys to the new building, creating a tense situation. The midwives are forced to relent, and Mrs. Ma, the landlord, agrees to let them stay temporarily, using the back door. The search for a clinic continues as a new baby enters their care. Sister Veronica and Nurse Crane find the girl crying in a cardboard box, and Mrs. Ma names her Beryl, honoring Sister Veronica's birth name. Derek reveals that the area is notorious for organized crime, controlled by a triad gangster known as the Cormorant. The midwives must now find a new building, requesting an old, unused one owned by the army. Back in Poplar, the midwives tackle various tasks, including costume production for the Christmas carnival and household management. Timothy accepts an offer to shadow a respected surgeon, and a holiday party is organized at Nonnatus House. Trixie delivers Queenie's baby by forceps, but the party turns chaotic. Mr. Fischer, Mr. Turner's patient, passes away, surrounded by caretakers. Shelagh discovers letters and Esther's belongings at Mrs. Ma's, leading her to Sister Edith at the sanatorium. Esther had a child with the Cormorant, and Sister Edith provides a final hiding place. Esther and Christopher are found in an overcrowded building, where Esther has given birth to another child, Beryl. Christopher has a cancerous tumor, and the Cormorant threatens to keep him in Hong Kong. Fred and Dr. Turner learn of the Cormorant's plans and confront Grace's husband, who is the driver. Grace warns Derek, and the midwives are brought to the Cormorant, who gambles with Dr. Turner over Christopher's fate. Dr. Turner convinces the Cormorant of the benefits of sending Christopher to England. As the English contingent prepares to return home, Sister Hilda delivers a baby, naming her 'Nurse' in honor of Nurse Crane. Sister Hilda stays in Hong Kong to establish the new clinic, while Christopher is sent to England in May's sweater, and Esther is reunited with Beryl. The story concludes with everyone returning home to London just in time for Christmas.